Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance.

ABSTRACT:

Background/aims

The aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM).

Methods

A cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose ≥ 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281).

Results

The GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin

SUBMITTER: Yang SJ 

PROVIDER: S-EPMC3654128 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature