Efficacy of cilostazol on uncontrolled coronary vasospastic angina: a pilot study.

ABSTRACT:

Background

Although an angina attack by vasospastic angina (VSA) can usually be relieved or controlled with nitrates and calcium channel blockers (CCBs), there are some patients who cannot be controlled even by higher doses and combinations of these drugs. Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cyclic adenosine monophosphate (cAMP) contents. A stimulation of cAMP signal transduction increases coronary nitric oxide production. We examined whether cilostazol improved angina symptoms in patients with VSA uncontrolled by conventional treatment.

Methods

This study was conducted in a prospective, multicenter, nonrandomized manner. The subject consisted of 21 patients (13 men, 57 ± 9 year-old) who were diagnosed with VSA and had at l

SUBMITTER: Yoo SY 

PROVIDER: S-EPMC3654168 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature