Minimizing human infection from Escherichia coli O157:H7 using GUMBOS.

ABSTRACT:

Objectives

Reduction in faecal shedding of Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) in food-producing animals is a viable strategy to minimize human disease initiated by exposure to these microorganisms. To this end, an intervention strategy involving the electrostatic hybridization of two commonly used anti-infective agents for veterinary practice (i.e. chlorhexidine and ampicillin) was evaluated to curtail EHEC-transmitted disease from ruminant sources. Chlorhexidine di-ampicillin is a novel group of uniform material based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antimicrobial ions, chlorhexidine and ampicillin.

Methods

Antibacterial activities for chlorhexidine diacetate, sodium ampicillin,

SUBMITTER: Cole MR 

PROVIDER: S-EPMC3654221 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature