Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.

ABSTRACT:

Background & aims

The diagnosis of drug-induced liver injury relies on exclusion of other causes, including viral hepatitis A, B, and C. Hepatitis E virus (HEV) infection has been proposed as another cause of suspected drug-induced liver disease. We assessed the frequency of HEV infection among patients with drug-induced liver injury in the United States.

Methods

The Drug-Induced Liver Injury Network (DILIN) is a prospective study of patients with suspected drug-induced liver injury; clinical information and biological samples are collected to investigate pathogenesis and disease progression. We analyzed serum samples, collected from patients enrolled in DILIN, for immunoglobulin (Ig) G and IgM against HEV; selected samples were tested for HEV RNA.

Results

Among 318 p

SUBMITTER: Davern TJ 

PROVIDER: S-EPMC3654540 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature