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High-density lipoproteins delivering interleukin-15.

ABSTRACT: Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation.

SUBMITTER: Ochoa MC 

PROVIDER: S-EPMC3654572 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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High-density lipoproteins delivering interleukin-15.

Ochoa Maria C MC   Melero Ignacio I   Berraondo Pedro P  

Oncoimmunology 20130401 4

Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation. ...[more]