Chlamydia muridarum enters a viable but non-infectious state in amoxicillin-treated BALB/c mice.

ABSTRACT: In culture, exposure to penicillin and other stressors induce chlamydiae to enter a non-infectious but viable state termed persistence. Chlamydiae may reenter their normal developmental cycle after stressor removal. Though aberrant RB similar to those present in culture models of persistence have been observed within infected tissues, the existence of persistent chlamydiae has not been definitively demonstrated in vivo. As a result, the role of persistent organisms in pathogenesis is undefined. In order to establish an experimentally tractable model of in vivo persistence, Chlamydia muridarum vaginally-infected mice were gavaged with either water or amoxicillin (amox). Vaginal swabs were collected for chlamydial titration and RNA isolated for quantification of pre-16s rRNA. Uterine tissue

SUBMITTER: Phillips Campbell R 

PROVIDER: S-EPMC3654801 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature