Determinants of epidermal nerve fibre density in antiretroviral-naive HIV-infected individuals.

ABSTRACT:

Objectives

Distal leg epidermal nerve fibre density (ENFD) is a validated predictor of small unmyelinated nerve fibre damage and neuropathy risk in HIV infection. As pre-existing damage may increase the risk of neuropathy following antiretroviral (ARV) therapy, particularly when the regimen contains stavudine (d4T), we assessed the relationship between ENFD and various parameters including mitochondrial factors in HIV-infected Thai individuals naïve to ARV therapy.

Methods

Distal leg and proximal thigh ENFDs were quantified in HIV-infected Thai individuals without neuropathy prior to randomization to a HIV clinical trial that focused on mitochondrial toxicity issues. We assessed their association with various clinical and immunovirological parameters as well as with peripher

SUBMITTER: Shikuma C 

PROVIDER: S-EPMC3654839 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature