Altering physiological networks using drugs: steps towards personalized physiology.

ABSTRACT:

Background

The rise of personalized medicine has reminded us that each patient must be treated as an individual. One factor in making treatment decisions is the physiological state of each patient, but definitions of relevant states and methods to visualize state-related physiologic changes are scarce. We constructed correlation networks from physiologic data to demonstrate changes associated with pressor use in the intensive care unit.

Methods

We collected 29 physiological variables at one-minute intervals from nineteen trauma patients in the intensive care unit of an academic hospital and grouped each minute of data as receiving or not receiving pressors. For each group we constructed Spearman correlation networks of pairs of physiologic variables. To visualize drug-associ

SUBMITTER: Grossman AD 

PROVIDER: S-EPMC3654899 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature