The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat.

ABSTRACT:

Background

Iron deficiency anaemia during pregnancy is a global problem, with short and long term consequences for maternal and child health. Animal models have demonstrated that the developing fetus is vulnerable to maternal iron restriction, impacting on postnatal metabolic and blood pressure regulation. Whilst long-term outcomes are similar across different models, the commonality in mechanistic events across models is unknown. This study examined the impact of iron deficiency on maternal and fetal iron homeostasis in two strains of rat.

Methods

Wistar (n=20) and Rowett Hooded Lister (RHL, n=19) rats were fed a control or low iron diet for 4 weeks prior to and during pregnancy. Tissues were collected at day 21 of gestation for analysis of iron content and mRNA/protein exp

SUBMITTER: Cornock R 

PROVIDER: S-EPMC3654972 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature