Aberrant BAF57 signaling facilitates prometastatic phenotypes.

ABSTRACT:

Purpose

BAF57, a component of the switching-defective and sucrose nonfermenting (SWI/SNF) chromatin-remodeling complex conglomerate, modulates androgen receptor activity to promote prostate cancer. However, the molecular consequences of tumor-associated BAF57 expression have remained undefined in advanced disease such as castration-resistant prostate cancer and/or metastasis.

Experimental design

Clinical human specimens of primary and metastatic prostate cancer were immunohistochemically examined for tumor-grade association of BAF57 expression. Global gene expression analyses were conducted in models mimicking tumor-associated BAF57 expression. Aberrant BAF57-dependent gene expression changes, bypass of androgen-mediated signaling, and chromatin-specific SWI/SNF complex alte

SUBMITTER: Balasubramaniam S 

PROVIDER: S-EPMC3655134 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature