Neural effects of positive and negative incentives during marijuana withdrawal.

ABSTRACT: In spite of evidence suggesting two possible mechanisms related to drug-seeking behavior, namely reward-seeking and harm avoidance, much of the addiction literature has focused largely on positive incentivization mechanisms associated with addiction. In this study, we examined the contributing neural mechanisms of avoidance of an aversive state to drug-seeking behavior during marijuana withdrawal. To that end, marijuana users were scanned while performing the monetary incentive delay task in order to assess positive and negative incentive processes. The results showed a group x incentive interaction, such that marijuana users had greater response in areas that underlie reward processes during positive incentives while controls showed greater response in the same areas, but to negative ince

SUBMITTER: Filbey FM 

PROVIDER: S-EPMC3655173 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature