The limits of genome-wide methods for pharmacogenomic testing.

ABSTRACT:

Objective

The goal of pharmacogenomics is the translation of genomic discoveries into individualized patient care. Recent advances in the means to survey human genetic variation are fundamentally transforming our understanding of the genetic basis of interindividual variation in therapeutic response. The goal of this study was to systematically evaluate high-throughput genotyping technologies for their ability to assay variation in pharmacogenetically important genes (pharmacogenes). These platforms are either being proposed for or are already being widely used for clinical implementation; therefore, knowledge of coverage of pharmacogenes on these platforms would serve to better evaluate current or proposed pharmacogenetic association studies.

Method

Among the genes included

SUBMITTER: Gamazon ER 

PROVIDER: S-EPMC3655533 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature