Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility.

ABSTRACT:

Background

Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development.

Methods

We genotyped 10 potentially functional single nucleotide polymorphisms (SNPs) in 7 DNA double-strand break repair pathway genes (XRCC3, BRCA2, RAG1, XRCC5, LIG4, XRCC4 and ATM) in a case-control study including 384 glioma patients and 384 cancer-free controls in a Chinese Han population. Genotypes were determined using the OpenArray platform.

Results

In the single-locus analysis there was a significant association between gliomas and the LIG4 rs1805388

SUBMITTER: Zhao P 

PROVIDER: S-EPMC3655843 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature