A prospective study of leukocyte telomere length and risk of renal cell carcinoma.

ABSTRACT:

Background

It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively.

Methods

We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukocyte telomere length in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ORs and 95% confidence intervals (CI) were estimated using conditional logistic regression.

Results

Leukocyte telomere length was not significantly associated with future risk of RCC (highest quartile vs

SUBMITTER: Hofmann JN 

PROVIDER: S-EPMC3655903 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature