A specific immune transcriptomic profile discriminates chronic kidney disease patients in predialysis from hemodialyzed patients.

ABSTRACT:

Background

Chronic kidney disease (CKD) patients present a complex interaction between the innate and adaptive immune systems, in which immune activation (hypercytokinemia and acute-phase response) and immune suppression (impairment of response to infections and poor development of adaptive immunity) coexist. In this setting, circulating uremic toxins and microinflammation play a critical role. This condition, already present in the last stages of renal damage, seems to be enhanced by the contact of blood with bioincompatible extracorporeal hemodialysis (HD) devices. However, although largely described, the cellular machinery associated to the CKD- and HD-related immune-dysfunction is still poorly defined. Understanding the mechanisms behind this important complication may generate

SUBMITTER: Zaza G 

PROVIDER: S-EPMC3655909 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature