Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population.

ABSTRACT:

Objective

Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population.

Methods

We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing

SUBMITTER: Hu D 

PROVIDER: S-EPMC3655942 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature