Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

ABSTRACT:

Background

The pathogenic non-cultivable treponemes include three subspecies of Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and the unclassified Fribourg-Blanc treponeme (Simian isolate). These treponemes are morphologically indistinguishable and antigenically and genetically highly similar, yet cross-immunity is variable or non-existent. Although all of these organisms cause chronic, multistage skin and systemic disease, they have historically been classified by mode of transmission, clinical presentations and host ranges. Whole genome studies underscore the high degree of sequence identity among species, subspecies and strains, pinpointing a limited number of genomic regions for variation. Many of these "hot spots" include members of the

SUBMITTER: Centurion-Lara A 

PROVIDER: S-EPMC3656149 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature