Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data.

ABSTRACT: There is increasing evidence that heritable variation in gene expression underlies genetic variation in susceptibility to disease. Therefore, a comprehensive understanding of the similarity between relatives for transcript variation is warranted--in particular, dissection of phenotypic variation into additive and non-additive genetic factors and shared environmental effects. We conducted a gene expression study in blood samples of 862 individuals from 312 nuclear families containing MZ or DZ twin pairs using both pedigree and genotype information. From a pedigree analysis we show that the vast majority of genetic variation across 17,994 probes is additive, although non-additive genetic variation is identified for 960 transcripts. For 180 of the 960 transcripts with non-additive genetic var

SUBMITTER: Powell JE 

PROVIDER: S-EPMC3656157 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature