Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2.

ABSTRACT: The endothelin-A receptor (Ednra) is involved in several physiological, pathological, and developmental pathways. Known for its function in vasoconstriction after being activated by endothelin-1, Ednra also controls cephalic neural crest cell development and appears to play a role in several pathologies, including cancer and periodontitis. However, the mechanisms regulating Ednra expression have not been identified despite its important functions. In this study, we investigated the role progesterone plays in Ednra gene expression in vivo and in vitro. In mice, pregnancy promotes Ednra expression in the heart, kidney, lung, uterus, and placenta, and the up-regulation is mediated by progesterone. We determined that the conserved region between -5.7 and -4.2 kb upstream of the mouse Ednra gen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3656236 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature