Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.

ABSTRACT:

Background

Herpes simplex virus resistance to acyclovir is well described in immune-compromised patients. Management of prolonged infection and recurrences in such patients may be problematic.

Methods

A patient with neuroblastoma developed likely primary herpes gingivostomatitis shortly after starting a course of chemotherapy, with spread to the eye during treatment with acyclovir. Viral isolates were serially obtained from separate sites after treatment was begun and tested for susceptibility to acyclovir and foscarnet by plaque reduction and plating efficiency assays. The thymidine kinase and DNA polymerase genes from each isolate were sequenced.

Results

Initial isolates from a throat swab, an oral lesion, and conjunctiva were resistant to acyclovir within 13 days o

SUBMITTER: Karaba AH 

PROVIDER: S-EPMC3656553 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature