Ontology highlight
ABSTRACT:
SUBMITTER: Warren L
PROVIDER: S-EPMC3656821 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cell stem cell 20100930 5
Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPSCs toward clinically useful cell types are lacking. Here we describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses ...[more]