Activation of the kinin B1 receptor attenuates melanoma tumor growth and metastasis.

ABSTRACT: Melanoma is a very aggressive tumor that does not respond well to standard therapeutic approaches, such as radio- and chemotherapies. Furthermore, acquiring the ability to metastasize in melanoma and many other tumor types is directly related to incurable disease. The B1 kinin receptor participates in a variety of cancer-related pathophysiological events, such as inflammation and angiogenesis. Therefore, we investigated whether this G protein-coupled receptor plays a role in tumor progression. We used a murine melanoma cell line that expresses the kinin B1 receptor and does not express the kinin B2 receptor to investigate the precise contribution of activation of the B1 receptor in tumor progression and correlated events using various in vitro and in vivo approaches. Activation of the kini

SUBMITTER: Dillenburg-Pilla P 

PROVIDER: S-EPMC3656876 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature