Whole-genome annotation by using evidence integration in functional-linkage networks.

ABSTRACT: The advent of high-throughput biology has catalyzed a remarkable improvement in our ability to identify new genes. A large fraction of newly discovered genes have an unknown functional role, particularly when they are specific to a particular lineage or organism. These genes, currently labeled "hypothetical," might support important biological cell functions and could potentially serve as targets for medical, diagnostic, or pharmacogenomic studies. An important challenge to the scientific community is to associate these newly predicted genes with a biological function that can be validated by experimental screens. In the absence of sequence or structural homology to known genes, we must rely on advanced biotechnological methods, such as DNA chips and protein-protein interaction screens as

SUBMITTER: Karaoz U 

PROVIDER: S-EPMC365715 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature