Transgenic male mating advantage provides opportunity for Trojan gene effect in a fish.

ABSTRACT: Genetically modified (GM) strains now exist for many organisms, producing significant promise for agricultural production. However, if these organisms have some fitness advantage, they may also pose an environmental harm when released. High mating success of GM males relative to WT males provides such an important fitness advantage. Here, we provide documentation that GM male medaka fish modified with salmon growth hormone possess an overwhelming mating advantage. GM medaka offspring possess a survival disadvantage relative to WT, however. When both of these fitness components are included in our model, the transgene is predicted to spread if GM individuals enter wild populations (because of the mating advantage) and ultimately lead to population extinction (because of the viability disadv

SUBMITTER: Howard RD 

PROVIDER: S-EPMC365723 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature