Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension.

ABSTRACT: We have previously shown that angiotensin II type 1 receptor-associated protein (ATRAP/Agtrap) interacts with the angiotensin II type 1 receptor and promotes constitutive internalization of the receptor so as to inhibit the pathological activation of its downstream signaling but preserve baseline physiological signaling activity. The present study was designed to investigate the role of renal ATRAP in angiotensin II-dependent hypertension. We generated transgenic mice dominantly expressing ATRAP in the renal tubules, including renal distal tubules. The renal ATRAP transgenic mice exhibited no significant change in blood pressure at baseline on normal salt diet. However, in the renal ATRAP transgenic mice compared with wild-type mice, the following took place: (1) the development of high bl

SUBMITTER: Wakui H 

PROVIDER: S-EPMC3657390 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature