Chronic cerebrospinal venous insufficiency: case-control neurosonography results.

ABSTRACT:

Objective

Chronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the pathophysiology of multiple sclerosis (MS). We sought to determine whether neurosonography (NS) provides reliable information on cerebral venous outflow patterns specific to MS.

Methods

This was a single-center, prospective case-control study of volunteer MS and non-MS participants. A neurosonologist, blind to the subjects' diagnosis, used high-resolution B-mode imaging with color and spectral Doppler to systematically investigate, capture, and record extracranial and intracranial venous drainage. These neuroimaging results were evaluated and scored by an expert blinded to subjects' information and with no interactions with the participants.

Results

Altogether, 276 subjects were st

SUBMITTER: Barreto AD 

PROVIDER: S-EPMC3657573 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature