Cooperative melting in caged dimers with only two DNA duplexes.

ABSTRACT: Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

SUBMITTER: Eryazici I 

PROVIDER: S-EPMC3657612 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature