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Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.

ABSTRACT: Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor eradication by T cells required high affinities of the targeted peptides for major histocompatibility complex (MHC) class I. Affinities of at least 10 nM were required for relapse-free regression. Only high-affinity peptide-MHC interactions led to efficient cross-presentation of antigen, thereby stimulating cognate T cells to secrete cytokines. These findings highlight the importance of targeting peptides with high affinity for MHC class I when designing T cell-based immunotherapy.

SUBMITTER: Engels B

PROVIDER: S-EPMC3658176 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.

Engels Boris B Engelhard Victor H VH Sidney John J Sette Alessandro A Binder David C DC Liu Rebecca B RB Kranz David M DM Meredith Stephen C SC Rowley Donald A DA Schreiber Hans H

Cancer cell 20130401 4

Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor eradication by T cells required high affinities of the targeted peptides for major histocompatibility complex (MHC) class I. Affinities of at least 10 nM were required for relapse-free regression. Only high-affinity peptide-MHC interactions led to efficient cross-presentation of antigen, thereby stimulating cognate T cells to secrete cytokines. Thes ...[more]

PMID: 23597565

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