Dissecting the energy metabolism in Mycoplasma pneumoniae through genome-scale metabolic modeling.

ABSTRACT: Mycoplasma pneumoniae, a threatening pathogen with a minimal genome, is a model organism for bacterial systems biology for which substantial experimental information is available. With the goal of understanding the complex interactions underlying its metabolism, we analyzed and characterized the metabolic network of M. pneumoniae in great detail, integrating data from different omics analyses under a range of conditions into a constraint-based model backbone. Iterating model predictions, hypothesis generation, experimental testing, and model refinement, we accurately curated the network and quantitatively explored the energy metabolism. In contrast to other bacteria, M. pneumoniae uses most of its energy for maintenance tasks instead of growth. We show that in highly linear networks the pr

SUBMITTER: Wodke JA 

PROVIDER: S-EPMC3658275 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature