Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity.

ABSTRACT:

Purpose of review

The present review discusses the physiological functions of selected caspase recruitment domain (CARD)-containing sensor and adaptor proteins and their role in the pathogenesis of intestinal diseases.

Recent findings

Myeloid and lymphoid cells as well as intestinal epithelial cells express several intracellular CARD-containing proteins. CARD-containing sensors, particularly NOD1 (CARD4), NOD2 (CARD15) and IPAF (CARD12), have an important role in the detection of conserved microbial structures of invading microbial pathogens. Upon ligand recognition and activation, the sensors interact through CARD domains with downstream CARD-containing adaptors including CARD9, RIP2 (CARD3) and ASC (CARD5). Recent data suggest that multiple signaling pathways from Toll-lik

SUBMITTER: Hruz P 

PROVIDER: S-EPMC3658451 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature