Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab.

ABSTRACT:

Background

Phosphatidylinositol 3-kinase (PI3K) pathway activation has been suggested to negatively influence response to anti-HER2 therapy in breast cancer patients. The present study focused on mutations of the PIK3CA gene, encoding one of the two PI3K subunits.

Methods

PIK3CA mutations were assessed by direct sequencing in 80 HER2-positive patients treated with 1 year of trastuzumab. All patients preoperatively received four cycles of anthracycline-based chemotherapy, followed by four cycles of docetaxel and 1 year of trastuzumab, starting either before surgery with the first cycle of docetaxel and continuing after surgery (neoadjuvant trastuzumab arm, n=43), or only after surgery (adjuvant trastuzumab arm, n=37).

Results

PIK3CA mutations were found in 17 tumours (

SUBMITTER: Cizkova M 

PROVIDER: S-EPMC3658522 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature