Effects of idebenone on color vision in patients with leber hereditary optic neuropathy.

ABSTRACT:

Background

The authors investigated the correlation of protan and tritan color vision with disease characteristics in Leber hereditary optic neuropathy (LHON). The authors also characterized the therapeutic potential of idebenone in protecting patients from developing dyschromatopsia in LHON.

Methods

Color contrast data of 39 LHON patients participating in a randomized, double-blind placebo-controlled intervention study were evaluated. Patients reported disease onset <5 years before enrolment and were genetically confirmed. Protan and tritan color contrast sensitivity was measured using a computer graphics method in patients receiving idebenone (Catena; 900 mg/d; N = 28) or placebo (N = 11) for 6 months.

Results

Mean age of patients was 28.1 years, 87.2% were men, 76.

SUBMITTER: Rudolph G 

PROVIDER: S-EPMC3658961 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature