Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease.

ABSTRACT:

Background

Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn's disease (CD).

Methods

85 pediatric- and 117 adult-onset CD patients were tested for the three main NOD2 CD-associated variants (p.R702W, p.G908R and p.10007fs) and clinical data of at least two years of follow-up were compared regarding disease behaviour and activity, response to therapy and bone mineral density (BMD).

Results

Chronic active and moderate to severe course of CD is associated in patients with pediatric-onset (p=0.0001) and NOD2 variant alleles (p=0.0001). In pediatric-onset CD the average PCDAI-Score was significantly higher in patients carrying NOD2 variants (p=0.0008). In addition,

SUBMITTER: Posovszky C 

PROVIDER: S-EPMC3659055 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature