Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish.

ABSTRACT: The dorsal habenular nuclei of the zebrafish epithalamus have become a valuable model for studying the development of left-right (L-R) asymmetry and its function in the vertebrate brain. The bilaterally paired dorsal habenulae exhibit striking differences in size, neuroanatomical organization, and molecular properties. They also display differences in their efferent connections with the interpeduncular nucleus (IPN) and in their afferent input, with a subset of mitral cells distributed on both sides of the olfactory bulb innervating only the right habenula. Previous studies have implicated the dorsal habenulae in modulating fear/anxiety responses in juvenile and adult zebrafish. It has been suggested that the asymmetric olfactory-habenula pathway (OB-Ha), revealed by selective labeling fro

SUBMITTER: deCarvalho TN 

PROVIDER: S-EPMC3659297 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature