Relationship between monocyte/macrophage activation marker soluble CD163 and insulin resistance in obese and normal-weight subjects.

ABSTRACT:

Context

The relationship of monocyte/macrophage activation to insulin resistance in obesity is unknown.

Objective

To investigate a marker of macrophage activation, soluble CD163 (sCD163), in relationship to insulin resistance and metabolic parameters in obese and normal-weight subjects.

Design and participants

Ninety-five healthy subjects (65 obese and 30 normal-weight) were studied. Plasma concentrations of sCD163 were assessed, as well as markers of glucose homeostasis, anthropometrics, cytokines and adipokines. The relationships between sCD163 and these parameters were investigated, and multiple regression modelling assessing the contribution of sCD163 to insulin resistance (HOMA-IR) was performed.

Results

Soluble CD163 was significantly increased in obese s

SUBMITTER: Zanni MV 

PROVIDER: S-EPMC3660104 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature