Reconstituting protein interaction networks using parameter-dependent domain-domain interactions.

ABSTRACT:

Background

We can describe protein-protein interactions (PPIs) as sets of distinct domain-domain interactions (DDIs) that mediate the physical interactions between proteins. Experimental data confirm that DDIs are more consistent than their corresponding PPIs, lending support to the notion that analyses of DDIs may improve our understanding of PPIs and lead to further insights into cellular function, disease, and evolution. However, currently available experimental DDI data cover only a small fraction of all existing PPIs and, in the absence of structural data, determining which particular DDI mediates any given PPI is a challenge.

Results

We present two contributions to the field of domain interaction analysis. First, we introduce a novel computational strategy to merge dom

SUBMITTER: Memisevic V 

PROVIDER: S-EPMC3660195 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature