Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.

ABSTRACT: Breast cancer in young women is more aggressive with a poorer prognosis and overall survival compared to older women diagnosed with the disease. Despite recent research, the underlying biology and molecular alterations that drive the aggressive nature of breast tumors associated with breast cancer in young women have yet to be elucidated. In this study, we performed transcriptomic profile and network analyses of breast tumors arising in Middle Eastern women to identify age-specific gene signatures. Moreover, we studied molecular alterations associated with cancer progression in young women using cross-species comparative genomics approach coupled with copy number alterations (CNA) associated with breast cancers from independent studies. We identified 63 genes specific to tumors in young wo

SUBMITTER: Colak D 

PROVIDER: S-EPMC3660335 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature