Detection, distribution and characterization of novel superoxide dismutases from Yersinia enterocolitica Biovar 1A.

ABSTRACT:

Background

Superoxide dismutases (SODs) cause dismutation of superoxide radicals to hydrogen peroxide and oxygen. Besides protecting the cells against oxidative damage by endogenously generated oxygen radicals, SODs play an important role in intraphagocytic survival of pathogenic bacteria. The complete genome sequences of Yersinia enterocolitica strains show presence of three different sod genes. However, not much is known about the types of SODs present in Y. enterocolitica, their characteristics and role in virulence and intraphagocytic survival of this organism.

Methodology/principal findings

This study reports detection and distribution of the three superoxide dismutase (sodA, sodB and sodC) genes in 59 strains of Y. enterocolitica and related species. The majority (94%)

SUBMITTER: Dhar MS 

PROVIDER: S-EPMC3660340 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature