Mechanical compliance and immunological compatibility of fixative-free decellularized/cryopreserved human pericardium.

ABSTRACT:

Background

The pericardial tissue is commonly used to produce bio-prosthetic cardiac valves and patches in cardiac surgery. The procedures adopted to prepare this tissue consist in treatment with aldehydes, which do not prevent post-graft tissue calcification due to incomplete xeno-antigens removal. The adoption of fixative-free decellularization protocols has been therefore suggested to overcome this limitation. Although promising, the decellularized pericardium has not yet used in clinics, due to the absence of proofs indicating that the decellularization and cryopreservation procedures can effectively preserve the mechanical properties and the immunologic compatibility of the tissue.

Principal findings

The aim of the present work was to validate a procedure to prepare dec

SUBMITTER: Vinci MC 

PROVIDER: S-EPMC3660606 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature