Improved ancestry inference using weights from external reference panels.

ABSTRACT:

Motivation

Inference of ancestry using genetic data is motivated by applications in genetic association studies, population genetics and personal genomics. Here, we provide methods and software for improved ancestry inference using genome-wide single nucleotide polymorphism (SNP) weights from external reference panels. This approach makes it possible to leverage the rich ancestry information that is available from large external reference panels, without the administrative and computational complexities of re-analyzing the raw genotype data from the reference panel in subsequent studies.

Results

We extensively validate our approach in multiple African American, Latino American and European American datasets, making use of genome-wide SNP weights derived from large reference

SUBMITTER: Chen CY 

PROVIDER: S-EPMC3661048 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature