New and emerging therapies for bone metastases in genitourinary cancers.

ABSTRACT:

Context

Bone metastases are a common feature of advanced genitourinary malignancies and a prominent cause of morbidity and mortality.

Objective

The objective of this review is to discuss the incidence, pathophysiology, and management of bone metastases in the most prevalent genitourinary malignancies.

Evidence acquisition

We reviewed the relevant medical literature, with a particular emphasis on prospective randomized controlled trials. Much of the relevant clinical trial data focus on prostate cancer (PCa). We provide a nonsystematic review and our perspective on the available data.

Evidence synthesis

Clinical manifestations can include pain, hypercalcemia, pathologic fractures, and spinal cord compression. Optimal systemic therapy for skeletal metastases ofte

SUBMITTER: Saylor PJ 

PROVIDER: S-EPMC3661203 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature