Pretreatment antimullerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy.

ABSTRACT:

Objective

To identify factors associated with ovarian reserve impairment during and immediately after chemotherapy.

Design

Prospective cohort study.

Setting

Four university hospitals.

Patient(s)

Forty-six adolescent and young adult women with a new diagnosis of cancer requiring chemotherapy.

Intervention(s)

None.

Main outcome measure(s)

Measurements of ovarian reserve via levels of serum follicle-stimulating hormone, luteinizing hormone, estradiol, inhibin B, and antimüllerian hormone (AMH) as well as antral follicle counts and mean ovarian volume at 3-month intervals.

Result(s)

Changes in ovarian reserve were quantified for both the acute impact of treatment using linear regression and the longitudinal recovery after therapy using mixed-ef

SUBMITTER: Dillon KE 

PROVIDER: S-EPMC3661215 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature