Peripheral blood MDSCs, IL-10 and IL-12 in children with asthma and their importance in asthma development.

ABSTRACT:

Objective

To investigate myeloid-derived suppressor cell (MDSC) accumulation and interleukin 10 (IL-10) and interleukin 12 (IL-12) levels during the onset of asthma in both pediatric patients and mouse models, as well as their possible roles in the development of asthma.

Methods

Peripheral blood samples were gathered from children with asthma attacks (attack group) and alleviated asthma (alleviated group), as well as two control groups, children with pneumonia and healthy children. The pathological characteristics of asthma in asthmatic mice, budesonide-treated asthmatic mice, and normal control mice were also evaluated by immunohistochemistry (IHC) and hematoxylin and eosin (H&E) staining.

Results

MDSC accumulation and serum IL-10 levels were significantly elevated i

SUBMITTER: Zhang YL 

PROVIDER: S-EPMC3661689 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature