Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial.

ABSTRACT:

Objective

Among adolescents with type 2 diabetes, there is limited information regarding incidence and progression of hypertension and microalbuminuria. Hypertension and microalbuminuria assessments made during the TODAY clinical trial were analyzed for effect of treatment, glycemic control, sex, and race/ethnicity.

Research design and methods

A cohort of 699 adolescents, 10-17 years of age, <2 years duration of type 2 diabetes, BMI ≥ 85%, HbA1c ≤ 8% on metformin therapy, controlled blood pressure (BP), and calculated creatinine clearance >70 mL/min, were randomized to metformin, metformin plus rosiglitazone, or metformin plus intensive lifestyle intervention. Primary study outcome was loss of glycemic control for 6 months or sustained metabolic decompensation requiring insu

SUBMITTER: TODAY Study Group 

PROVIDER: S-EPMC3661847 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature