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An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.

ABSTRACT: An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.

SUBMITTER: Tsatsaroni A

PROVIDER: S-EPMC3661977 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.

Tsatsaroni Alexandra A Zoidis Grigoris G Zoumpoulakis Panagiotis P Tsotinis Andrew A Taylor Martin C MC Kelly John M JM Fytas George G

Tetrahedron letters 20130601 25

An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented. ...[more]

PMID: 23794760

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