Copper-catalyzed diastereoselective arylation of tryptophan derivatives: total synthesis of (+)-naseseazines A and B.

ABSTRACT: A copper-catalyzed arylation of tryptophan derivatives is reported. The reaction proceeds with high site- and diastereoselectivity to provide aryl pyrroloindoline products in one step from simple starting materials. The utility of this transformation is highlighted in the five-step syntheses of the natural products (+)-naseseazine A and B.

SUBMITTER: Kieffer ME 

PROVIDER: S-EPMC3662218 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature