The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy.

ABSTRACT:

Objective

To study 5-HT transport and 5-HT1A receptors in temporal lobe epilepsy (TLE) and depression.

Methods

Thirteen patients had PET with [(11)C]DASB for 5-HTT and [(18)F]FCWAY for 5-HT1A receptor binding, MRI, and psychiatric assessment. Sixteen healthy volunteers had [(11)C]DASB, 19 had [(18)F]FCWAY, and 6 had both PET studies. We used a reference tissue model to estimate [(11)C]DASB binding. [(18)F]FCWAY volume of distribution was corrected for plasma-free fraction. Images were normalized to common space. The main outcome was the regional asymmetry index. Positive asymmetry indicates relative reduced binding (reflecting transporter activity) ipsilateral to epileptic foci.

Results

Mean regional [(11)C]DASB binding and asymmetry did not differ between patients an

SUBMITTER: Martinez A 

PROVIDER: S-EPMC3662359 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature