Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target.

ABSTRACT:

Background

Herpes viruses are important human pathogens that can cause mild to severe lifelong infections with high morbidity. They remain latent in the host cells and can cause recurrent infections that might prove fatal. These viruses are known to infect the host cells by causing the fusion of viral and host cell membrane proteins. Fusion is achieved with the help of conserved fusion machinery components, glycoproteins gB, heterodimer gH-gL complex along with other non-conserved components. Whereas, another important glycoprotein gD without which viral entry to the cell is not possible, acts as a co-activator for the gB-gH-gL complex formation. Thus, this complex formation interface is the most promising drug target for the development of novel anti-herpes drug candidates. In the

SUBMITTER: Basha SH 

PROVIDER: S-EPMC3662606 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature