The top-scoring 'N' algorithm: a generalized relative expression classification method from small numbers of biomolecules.

ABSTRACT:

Background

Relative expression algorithms such as the top-scoring pair (TSP) and the top-scoring triplet (TST) have several strengths that distinguish them from other classification methods, including resistance to overfitting, invariance to most data normalization methods, and biological interpretability. The top-scoring 'N' (TSN) algorithm is a generalized form of other relative expression algorithms which uses generic permutations and a dynamic classifier size to control both the permutation and combination space available for classification.

Results

TSN was tested on nine cancer datasets, showing statistically significant differences in classification accuracy between different classifier sizes (choices of N). TSN also performed competitively against a wide variety of di

SUBMITTER: Magis AT 

PROVIDER: S-EPMC3663421 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature