SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

ABSTRACT:

Background

A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular block. However, other independent replication studies are required to validate the result. This study assessed associations between rs3825214 and ECG parameters, AF, and ventricular tachycardia (VT) in a Chinese Han population.

Methodology/principal findings

To assess the association between rs3825214 and AF and VT, we carried out case-control association studies with 692 AF patients (including 275 lone AF pati

SUBMITTER: Zang X 

PROVIDER: S-EPMC3663751 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature